Cymphony Bio - Technology

Our Technology

The bubble

Dynamic Interface Printing (DIP) leverages a controlled bubble to rapidly create complex 3D structures from photosensitive inks within seconds. Our innovative modular print head, when submerged, forms one or more interfaces, boosting biological throughput significantly.

Unlike the rigid polymer membranes used in conventional methods, DIP utilises a fluid interface, allowing continuous structure formation while being supported by surrounding pre-polymer. This approach prevents collapse of soft materials, while also reducing damage and stress common in layer-by-layer processes.

Our fluid interface also allows for acoustic modulation, distinguishing it from traditional techniques. This capability supports high-throughput fabrication across diverse materials, precise homogenization of suspensions, and intricate 3D cellular patterning—all with a single print head.

Low contact printing

Utilising an air-liquid meniscus as the fabrication interface enables high-speed low contact printing of delicate structures within seconds

Interface modulation

Acoustic modulation unlocks a greater gamut of material processing ranges, whilst enabling cellular aggregation and patterning

Our Technology

Flexibility

We use cell-friendly 405 nm light to create precise 3D scaffolds, offering you the flexibility to choose the right material for your application. Continuous translation in DIP ensures low optical doses (< 30 mJ/cm²) and minimal photo-initiator concentrations (e.g., 1 mg/mL LAP), maintaining cell viability throughout the process.

Our modular print head design allows compatibility with a wide range of consumables, such as vials, cuvettes, petri dishes, and multi-well plates, ensuring minimal disruption to your established biological workflows. The multi-interface print head also allows simultaneous printing into multiple wells, optimizing throughput for high-density well plates.

Materials

DIP utilises 405 nm giving you the flexility to use a wide variety photopolymers and bioinks

Consumables

Use any print container in which the print head can be inserted, including vials, cuvettes, petri-dishes and multi-well plates.

Our Technology

Control

Achieving uniform dispersion of cells or granular additives within the printed construct is essential for consistent and repeatable results. Our pressurisation control system ensures controlled homogenisation of materials before and during printing. When combined with high-throughput fabrication, this approach effectively eliminates concentration gradients caused by particle settling whilst significantly augmenting encapsulation efficiency (> 2X).

Additionally, acoustic modulation of our air-liquid boundary enables precise three-dimensional cellular and granular positioning throughout the structure. We can achieve both streaming-based aggregation at the printing interface useful for forming high-density structures with a fewer number of cells or hydrodynamic-based patterning, contingent on the print head's shape, frequency, and amplitude—all with a single print head.

Mixing

Using our pressurisation control, we can uniformly homogenise materials both prior and during printing. Ensuring an even dispersion of cells throughout the construct

Patterning

Acoustic modulation of the air-liquid interface during printing, enables three-dimensional cellular patterning or aggregation

Our Technology

Complexity

By using a bubble as the printing surface instead of a solid membrane, you can easily create more complex structures. Printed objects can pass back through the bubble, enabling the encapsulation of structures in different materials. This allows for the placement of multiple cell types in close proximity while maintaining distinct regions within your designs. Additionally, fragile scaffolds can be reinforced with more durable materials, facilitating connections to external devices for nutrient delivery to your cells.

Our print head also doubles as a liquid transfer tool between print volumes, allowing you to automate tasks that would otherwise require tedious manual handling.

Multi-material printing

DIP's pressurisation control facilitates liquid handling , allowing for automated liquid transfer for multi-material structures.

Over-printing

Our air-liquid interface permits structures to pass through, enabling seamless overprinting